Solvent Experimental Binding Free Energy (kcal / mol) dielectric constant water content (mol%) Predicted Binding Free Energy (kcal / mol) chloroform -14.37 4.71 0 -14.38217 dichloromethane -9.37 8.93 0 -9.47592 acetone -7.57 20.49 0 -6.38653 acetonitrile -7.04 35.69 0 -5.37013 DMSO -5.84 46.83 0.003 -5.0202 DMSO + 2.5% H2O -3.64 49.65 0.092 -4.24889 DMSO + 5% H2O -3.03 52.08 0.17 -3.57894 DMSO + 10% H2O -2.5 56.17 0.3 -2.47057 "1,2-dichloroethane" -8.7 10.125 0 -8.82963 nitrobenzene + 1.2% H2O -6.8 35.5 0.016 -5.24946