Apoptosis is a common host response to virus infection. The extent and timing of apoptosis following infection is controlled by the balance between the strength of signals that activate death signaling and those that promote the survival of cells. In many cell types, infection with Mammalian orthoreovirus (reovirus) results in induction of cell death by apoptosis late in infection. In this study, we uncovered that WD repeat-containing protein 81 (WDR81) is required for apoptosis induction after reovirus infection. The requirement for WDR81 for apoptosis induction is not unique to reovirus because cells lacking WDR81 are also resistant to apoptosis induced by other agonists that trigger the extrinsic apoptotic pathway. We find that in cells deficient in WDR81, expression of several pro-survival genes is upregulated. The expression of these genes is controlled by the inhibitor of kB kinase complex (IKK)-Nuclear Factor of kB (NFκB) signaling pathway. When IKK signaling is blocked in WDR81-deficient cells, pro-survival gene expression is restored to normal levels and the cells regain their susceptibility to reovirus-induced death receptor-triggered apoptosis. Our work uncovers a new function for WDR81 in controlling apoptosis. Additionally, it reveals a previously unknown link between endosomally localized protein WDR81 and IKK-NFκB signaling.
Includes geodatabases with address points, street centerlines, parcels, county boundaries, and other assorted geographic units for years 2013, 2014, 2015, 2018. There is limited metadata for these data and they are not otherwise publicly available. Please contact the Indiana Geographic Information Office for more information.
Includes geodatabase with statewide address points, street centerlines, parcels, and county boundaries for Indiana, 2024. Also includes zipped shapefiles for individual counties, state geocoder, and real property geodatabase.
Includes geodatabase with statewide address points, street centerlines, parcels, and county boundaries for Indiana, 2023. Also includes zipped shapefiles for individual counties, state geocoder, and real property geodatabase.
Includes geodatabase with statewide address points, street centerlines, parcels, and county boundaries for Indiana, 2022. Also includes zipped shapefiles for individual counties, state geocoder.
Includes geodatabase with statewide address points, street centerlines, parcels, and county boundaries for Indiana, 2021. Also includes zipped geodatabases for individual counties, state geocoder, and real property geodatabase. See inventory and metadata files for more information.
Includes geodatabase with statewide address points, street centerlines, parcels, and county boundaries for Indiana, 2020. Also includes zipped shapefiles for individual counties, state geocoder, and real property geodatabase. See inventory file for full description of geodatabase layers, and metadata file for more information.
Spectroscopy data were collected on a BioTek Synergy H1 plate reader, then exported to and analyzed in Excel. 3D charts used in the manuscript were generated with OriginPro. Microscopy images are in proprietary .nd2 format of Nikon Elements software. .nd2 files were opened and processed with ImageJ. Gels were imaged on a BioRad Chemidoc.
Laughlin, P. M.; Young, K.; Gonzalez-Guiterrez, G.; Wang, J. C.-Y.,; Zlotnick, A. A narrow ratio of nucleic acid to SARS-CoV-2 N-protein enables phase separation. 2024.
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Raw data for "A narrow ratio of nucleic acid to SARS-CoV-2 N-protein enables phase separation"
This study addresses a debate on the nature of gamma (>30Hz) oscillations in language generation and structuring from a top-down vs. bottom-up chunking approach. Working within the framework of recent oscillatory models for syntax, we argue that a time-frequency analysis of electroencephalography at crucial points of recursions in bi-clausal wh-movement is probative of the role of gramma oscillations in the creation of referential dependencies nested into wh-dependencies, accounting for aspects of the expressive power of language.
The study proposes that gamma oscillations in frontotemporal circuitry create syntax-semantics objects in contrast with slow-rhythm entrainment of gamma oscillations tracking semantic fitness in bottom-up chunking. We show gamma power effects associated with aspects of anaphoric relations established in syntax vs. discourse during the processing of bi-clausal filler-gap dependencies. Despite equal semantic fitness across conditions for noun phrase modifiers (Mods) and noun complements (Comps), Mod-Comp modulations of ERPDs linked to anaphoric relations with early vs. late antecedents arose in referential processing aligned with gap positions, suggesting the gamma-based implementation of referential relations is induced by the re-representations of pronouns in complex filler-gap dependencies.
Cortical 𝛾-Oscillations Implement Basic Language Operations: Evidence from Electroencephalography in Anaphora During English Filler-gap Dependency Processing
The evigene_mosquito_anofun2016 archive package contains a complete, reconstructed gene set of Anopheles funestus, mosquito, produced with EvidentialGene methods. This file set includes gene sequences, annotations, analyses and summary documents.
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Genes of Anopheles funestus, mosquito reconstructed with EvidentialGene
The evigene_daphnia_pulex2017 archive package contains a complete, reconstructed gene set of Daphnia pulex, produced with EvidentialGene methods. This file set includes gene sequences, annotations, analyses and summary documents.
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Genes of Daphnia pulex reconstructed with EvidentialGene
The evigene_daphnia_magna2014 archive package contains a complete, reconstructed gene set of Daphnia magna, produced with EvidentialGene methods. This file set includes gene sequences, annotations, analyses and summary documents.
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Genes of Daphnia magna reconstructed with EvidentialGene
The evigene_shrimp_penamon2013 archive package contains a complete, reconstructed gene set of Penaeus monodon, tiger shrimp, produced with EvidentialGene methods. This file set includes gene sequences, annotations, analyses and summary documents.
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Genes of Penaeus monodon, tiger shrimp reconstructed with EvidentialGene
Accompanying dataset to the protocol published in Methods in Molecular Biology. Click on the PURL link below in the "External Files" section to download the dataset.
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Bioinformatics Analysis of Top-Down Mass Spectrometry Data with ProSight Lite
The evigene_mosquito_anoalb2016 archive package contains a complete, reconstructed gene set of Anopheles albimanus, mosquito, produced with EvidentialGene methods. This file set includes gene sequences, annotations, analyses and summary documents.
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Genes of Anopheles albimanus, mosquito reconstructed with EvidentialGene
The evigene_pig2018 download contains a complete, reconstructed gene set of model animal Pig, Sus scrofa, produced with EvidentialGene methods. This file set includes gene sequences, annotations, analyses and summary documents.
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Genes of the Pig, Sus scrofa, reconstructed with EvidentialGene
The evigene_killifish2014 archive package contains a complete, reconstructed gene set of Fundulus heteroclitus, atlantic killifish, produced with EvidentialGene methods. This file set includes gene sequences, annotations, analyses and summary documents.
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Genes of Fundulus heteroclitus, atlantic killifish reconstructed with EvidentialGene
The evigene_daphnia_galeata2016 archive package contains a complete, reconstructed gene set of Daphnia galeata, produced with EvidentialGene methods. This file set includes gene sequences, annotations, analyses and summary documents.
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Genes of Daphnia galeata reconstructed with EvidentialGene
The evigene_tick_rhipic2014 archive package contains a complete, reconstructed gene set of Rhipicephalus pulchellus, zebra tick, produced with EvidentialGene methods. This file set includes gene sequences, annotations, analyses and summary documents.
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Genes of Rhipicephalus pulchellus, zebra tick reconstructed with EvidentialGene
The evigene_whitefly_bemitab2017 archive package contains a complete, reconstructed gene set of Bemisia tabaci, whitefly, produced with EvidentialGene methods. This file set includes gene sequences, annotations, analyses and summary documents.
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Title:
Genes of Bemisia tabaci, whitefly reconstructed with EvidentialGene
The evigene_mosquito_aedes2016 archive package contains a complete, reconstructed gene set of Aedes aegypti, mosquito, produced with EvidentialGene methods. This file set includes gene sequences, annotations, analyses and summary documents.
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Title:
Genes of Aedes aegypti, mosquito reconstructed with EvidentialGene
Data are contained in a single zip file. Contents of the zip file are in a single directory with the name Supplement. That directory contains a pdf file called README.pdf describing the total contents. and Full Author List: Gary L. Pavlis, Department of Geological Sciences, 1001 East 10th Street, Indiana University, Bloomington, IN 47405 ( pavlis@indiana.edu); Karin Sigloch, Department of Earth and Environmental Sciences, Ludwig-Maximilians-Universitat, Theresienstrasse 41, D-80333, Munich, Germany ( sigloch@geophysik.uni-muenchen.de ); Scott Burdick, Department of Earth, Atmospheric, and Planetary Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts ( sburdick@mit.edu); Matthew J. Fouch, Department of Terrestrial Magnetism, Carnegie Institution of Washington,
5241 Broad Branch Road, NW, Washington, DC 20015 ( fouch@dtm.ciw.edu ); Frank Vernon, Institute of Geophysics and Planetary Physics (IGPP), University of California, San Diego, La Jolla, CA ( flvernon@ucsd.edu )
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"Unraveling the geometry of the Farallon Plate: Synthesis of three-dimensional imaging results from the USArray", electronic supplement
The evigene_daphnia_pulex2010 archive package contains a complete, reconstructed gene set of Daphnia pulex, produced with EvidentialGene methods. This file set includes gene sequences, annotations, analyses and summary documents.
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Title:
Genes of Daphnia pulex reconstructed with EvidentialGene
The evigene_seaurchin_lytvar2017 archive package contains a complete, reconstructed gene set of Lytechinus variegatus, green sea urchin, produced with EvidentialGene methods. This file set includes gene sequences, annotations, analyses and summary documents.
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Genes of Lytechinus variegatus, green sea urchin reconstructed with EvidentialGene
The evigene_cacao2013 archive package contains a complete, reconstructed gene set of Theobroma cacao, chocolate tree, produced with EvidentialGene methods. This file set includes gene sequences, annotations, analyses and summary documents.
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Genes of Theobroma cacao, chocolate tree reconstructed with EvidentialGene
The evigene_tick_ixoscap2014 archive package contains a complete, reconstructed gene set of Ixodes scapularis, deer tick, produced with EvidentialGene methods. This file set includes gene sequences, annotations, analyses and summary documents.
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Title:
Genes of Ixodes scapularis, deer tick reconstructed with EvidentialGene
Click on the PURL link below in the "Link(s) to data and video for this item" section to download the dataset.
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Data for "Spatially variable increase in rock uplift in the northern U.S. Cordillera recorded in the distribution of river knickpoints and incision depths"
